Cyclic Peptide-Based Sirtuin Substrates

Cyclic Peptide-Based Sirtuin Substrates

Di Chen, Lingling Yan, Wei-ping Zheng

In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring Nε-acetyl-lysine or Nε-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the kcat/KM ratios.

2019

SIRTUIN, deacylation, substrate, cyclic peptide

DOI: 10.3390/molecules24030424

Molecules

MDPI AG

Organic chemistry

EN