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                <text>Dominio científico: Coronavirus</text>
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              <text>New Metrics for Evaluating Viral Respiratory Pathogenesis.</text>
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              <text>Vineet D. Menachery, Lisa E Gralinski, Ralph S. Baric, Martin T. Ferris</text>
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              <text>Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.</text>
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              <text>DOI: 10.1371/journal.pone.0131451</text>
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              <text>PLoS ONE</text>
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