https://socictopen.socict.org/files/original/92c8edbbb6e63370f24242bb2277314b.pdf 46eae5f571ad24018d6957d4a32bd457 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antiplasmodial Activity of <i>p</i>-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections Creator An entity primarily responsible for making the resource Marcello Casertano, Marialuisa Menna, Caterina Fattorusso, Nicoletta Basilico, Silvia Parapini, Marco Persico, Concetta Imperatore Description An account of the resource Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control efforts and reversed gains in child survival. This paper describes a continuation of our ongoing efforts to investigate the effects against Plasmodium falciparum strains and human microvascular endothelial cells (HMEC-1) of a series of methoxy p-benzyl-substituted thiazinoquinones designed starting from a pointed antimalarial lead candidate. The data obtained from the newly tested compounds expanded the structure–activity relationships (SARs) of the thiazinoquinone scaffold, indicating that antiplasmodial activity is not affected by the inductive effect but rather by the resonance effect of the introduced group at the para position of the benzyl substituent. Indeed, the current survey was based on the evaluation of antiparasitic usefulness as well as the selectivity on mammalian cells of the tested p-benzyl-substituted thiazinoquinones, upgrading the knowledge about the active thiazinoquinone scaffold. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource thiazinoquinones, <i>Plasmodium falciparum</i>, quinone-derived antimalarial agents, marine inspired compounds, cytotoxicity, antiparasitic agents Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules25071530 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN