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                <text>Agricultura sostenible</text>
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                <text>Dominio científico: Agricultura sostenible</text>
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              <text>Gas Chromatography-Mass Spectrometry Analysis of Ulva fasciata (Green Seaweed) Extract and Evaluation of Its Cytoprotective and Antigenotoxic Effects</text>
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              <text>Idania Rodeiro, Sitlali Olguín, Rebeca Santes, José A. Herrera, Carlos L. Pérez, Raisa Mangas, Yasnay Hernández, Gisselle Fernández, Ivones Hernández, Sandra Hernández-Ojeda, Rafael Camacho-Carranza, Ana Valencia-Olvera, Jesús Javier Espinosa-Aguirre</text>
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              <text>The chemical composition and biological properties of Ulva fasciata aqueous-ethanolic extract were examined. Five components were identified in one fraction prepared from the extract by gas chromatography-mass spectrometry, and palmitic acid and its ethyl ester accounted for 76% of the total identified components. Furthermore, we assessed the extract’s antioxidant properties by using the DPPH, ABTS, and lipid peroxidation assays and found that the extract had a moderate scavenging effect. In an experiment involving preexposition and coexposition of the extract (1–500 µg/mL) and benzo[a]pyrene (BP), the extract was found to be nontoxic to C9 cells in culture and to inhibit the cytotoxicity induced by BP. As BP is biotransformed by CYP1A and CYP2B subfamilies, we explored the possible interaction of the extract with these enzymes. The extract (25–50 µg/mL) inhibited CYP1A1 activity in rat liver microsomes. Analysis of the inhibition kinetics revealed a mixed-type inhibitory effect on CYP1A1 supersome. The effects of the extract on BP-induced DNA damage and hepatic CYP activity in mice were also investigated. Micronuclei induction by BP and liver CYP1A1/2 activities significantly decreased in animals treated with the extract. The results suggest that Ulva fasciata aqueous-ethanolic extract inhibits BP bioactivation and it may be a potential chemopreventive agent.</text>
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              <text>2015</text>
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              <text>10.1155/2015/520598</text>
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              <text>Evidence-Based Complementary and Alternative Medicine</text>
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          <name>Publisher</name>
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              <text>Hindawi Limited</text>
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          <name>Coverage</name>
          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Other systems of medicine</text>
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              <text>&lt;a href="http://dx.doi.org/10.1155/2015/520598" target="_blank" rel="noreferrer noopener"&gt;http://dx.doi.org/10.1155/2015/520598&lt;/a&gt;</text>
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