https://socictopen.socict.org/files/original/210540210644b177e04eb27e01fe4d6c.pdf 146d2d42e2191de175461d9cf96305fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Celiac Immunogenic Potential of α-Gliadin Epitope Variants from <i>Triticum</i> and <i>Aegilops</i> Species Creator An entity primarily responsible for making the resource Carmen V. Ozuna, Francisco Barro, Ángela Ruiz-Carnicer, Isabel Comino, Verónica Segura, María de Lourdes Moreno, Miguel Ángel López-Casado, María Isabel Torres, Carolina Sousa Description An account of the resource The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet. Gluten is the main structural complex of wheat proteins and subjects affected by celiac disease (CD) cannot tolerate gluten protein. Within gluten proteins, &#945;-gliadins constitute the most immunogenic fraction since they contain the main T-cell stimulating epitopes (DQ2.5-glia-&#945;1, DQ2.5-glia-&#945;2, and DQ2.5-glia-&#945;3). In this work, the celiac immunotoxic potential of &#945;-gliadins was studied within Triticeae: diploid, tetraploid, and hexaploid species. The abundance and immunostimulatory capacity of CD canonical epitopes and variants (with one or two mismatches) in all &#945;-gliadin sequences were determined. The results showed that the canonical epitopes DQ2.5-glia-&#945;1 and DQ2.5-glia-&#945;3 were more frequent than DQ2.5-glia-&#945;2. A higher abundance of canonical DQ2.5-glia-&#945;1 epitope was found to be associated with genomes of the BBAADD, AA, and DD types; however, the abundance of DQ2.5-glia-&#945;3 epitope variants was very high in BBAADD and BBAA wheat despite their low abundance in the canonical epitope. The most abundant substitution was that of proline to serine, which was disposed mainly on the three canonical DQ2.5 domains on position 8. Interestingly, our results demonstrated that the natural introduction of Q to H at any position eliminates the toxicity of the three T-cell epitopes in the &#945;-gliadins. The results provided a rational approach for the introduction of natural amino acid substitutions to eliminate the toxicity of three T-cell epitopes, while maintaining the technological properties of commercial wheats. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource 33-mer, DQ2.5-glia-α1, DQ2.5-glia-α2, DQ2.5-glia-α3 epitopes, celiac disease, wheat species, α-gliadin Identifier An unambiguous reference to the resource within a given context 10.3390/nu11020220 Source A related resource from which the described resource is derived Nutrients Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nutrition. Foods and food supply Relation A related resource <a href="https://www.mdpi.com/2072-6643/11/2/220" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2072-6643/11/2/220</a>