Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

Kwonil Jung, Hui Hu, Bryan Eyerly, Zhongyan Lu, Juliet Chepngeno, Linda J. Saif

To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21–120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs.

2015

porcine deltacoronavirus, PDCoV, coronavirus, Viruses, strains, strain OH-FD22

DOI: 10.3201/eid2104.141859

Emerging Infectious Diseases

Centers for Disease Control and Prevention

Infectious and parasitic diseases, Medicine

EN