https://socictopen.socict.org/files/original/967a973f3bd39b0707437e4e91eeebbc.pdf 1b0885f711f457b2b8812a6675aa8c2b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Epidemiology of SARS-associated Coronavirus, Beijing Creator An entity primarily responsible for making the resource Wei Liu, Fang Tang, Arnaud Fontanet, Lin Zhan, Tian-Bao Wang, Pan-He Zhang, Yi-He Luan, Chao-Yang Cao, Qiu-Min Zhao, Xiaoming Wu, Zhong-Tao Xin, Shu-Qing Zuo, Laurence Baril, Astrid Vabret, Yiming Shao, Hong Yang, Wu-Chun Cao Description An account of the resource Single nucleotide variations (SNVs) at 5 loci (17564, 21721, 22222, 23823, and 27827) were used to define the molecular epidemiologic characteristics of severe acute respiratory syndrome–associated coronavirus (SARS-CoV) from Beijing patients. Five fragments targeted at the SNV loci were amplified directly from clinical samples by using reverse transcription–polymerase chain reaction (RT-PCR), before sequencing the amplified products. Analyses of 45 sequences obtained from 29 patients showed that the GGCTC motif dominated among samples collected from March to early April 2003; the TGTTT motif predominanted afterwards. The switch from GGCTC to TGTTT was observed among patients belonging to the same cluster, which ruled out the possibility of the coincidental superposition of 2 epidemics running in parallel in Beijing. The Beijing isolates underwent the same change pattern reported from Guangdong Province. The same series of mutations occurring in separate geographic locations and at different times suggests a dominant process of viral adaptation to the host. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource severe acute respiratory syndrome, molecular epidemiology, single nucleotide variation, RT-PCR, research, China Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1109.040773 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN