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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus</text>
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              <text>Ruth Harvey, Giada Mattiuzzo, Mark Hassall, Andrea Sieberg, Marcel A. Müller, Christian Drosten, Peter Rigsby, Christopher J. Oxenford</text>
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              <text>Middle East respiratory syndrome coronavirus (MERS-CoV) was detected in humans in 2012. Since then, sporadic outbreaks with primary transmission through dromedary camels to humans and outbreaks in healthcare settings have shown that MERS-CoV continues to pose a threat to human health. Several serologic assays for MERS-CoV have been developed globally. We describe a collaborative study to investigate the comparability of serologic assays for MERS-CoV and assess any benefit associated with the introduction of a standard reference reagent for MERS-CoV serology. Our study findings indicate that, when possible, laboratories should use a testing algorithm including &gt;2 tests to ensure correct diagnosis of MERS-CoV. We also demonstrate that the use of a reference reagent greatly improves the agreement between assays, enabling more consistent and therefore more meaningful comparisons between results.</text>
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              <text>Middle East respiratory syndrome coronavirus, MERS-CoV, Spike, Antibodies, diagnostics, serology</text>
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              <text>DOI: 10.3201/eid2510.190497</text>
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              <text>Emerging Infectious Diseases</text>
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              <text>Infectious and parasitic diseases, Medicine</text>
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              <text>EN</text>
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