Respiratory viral infections and the risk of rheumatoid arthritis

Respiratory viral infections and the risk of rheumatoid arthritis

Young Bin Joo, Youn-Hee Lim, Ki-Jo Kim, Kyung-Su Park, Yune-Jung Park

Abstract Background We aimed to investigate the effects of ambient respiratory viral infections in the general population on rheumatoid arthritis (RA) development. Methods Data of weekly incident RA (2012–2013) were obtained from the Korean National Health Insurance claims database, and those of weekly observations on eight respiratory viral infections were obtained from the Korea Centers for Disease Control and Prevention database. We estimated the percentage change in incident RA associated with ambient mean respiratory viral infections using a generalized linear model, after adjusting for time trend, air pollution, and meteorological data. Results A total of 24,117 cases of incident RA (mean age 54.7 years, 18,688 [77.5%] women) were analyzed. Ambient respiratory viral infections in the population were associated with a higher number of incident RA over time, and its effect peaked 6 or 7 weeks after exposure. Among the 8 viruses, parainfluenza virus (4.8% for 1% respiratory viral infection increase, 95% CI 1.6 to 8.1, P = .003), coronavirus (9.2%, 3.9 to 14.8, P 

2019

Respiratory viral infections, rheumatoid arthritis, risk factor

DOI: 10.1186/s13075-019-1977-9

Arthritis Research & Therapy

BMC

Diseases of the musculoskeletal system

EN