https://socictopen.socict.org/files/original/bf5bdd52a46c0564bd969e7e96ecc15a.pdf d175e02ed8dc6fde7a860dbf5053d5ba Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS Creator An entity primarily responsible for making the resource Lin Shu-Min, Lin Horng-Chyuan, Huang Kuo-Hsiung, Chou Chun-Liang, Wan Yung-Liang, Liu Chien-Ying, Wang Chun-Hua, Lin Tzou-Yien, Chung Kian, Kuo Han-Pin Description An account of the resource Abstract Background During the acute phase of severe acute respiratory syndrome (SARS), mononuclear cells infiltration, alveolar cell desquamation and hyaline membrane formation have been described, together with dysregulation of plasma cytokine levels. Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery. Methods To determine further the time course of recovery of lung inflammation, we investigated the HRCT and inflammatory profiles, and coronavirus persistence in bronchoalveolar lavage fluid (BALF) of 12 patients at recovery at 60 and 90 days. Results At 60 days, compared to normal controls, SARS patients had increased cellularity of BALF with increased alveolar macrophages (AM) and CD8 cells. HRCT scores were increased and correlated with T-cell numbers and their subpopulations, and inversely with CD4/CD8 ratio. TNF-α, IL-6, IL-8, RANTES and MCP-1 levels were increased. Viral particles in AM were detected by electron microscopy in 7 of 12 SARS patients with high HRCT score. On day 90, HRCT scores improved significantly in 10 of 12 patients, with normalization of BALF cell counts in 6 of 12 patients with repeat bronchoscopy. Pulse steroid therapy and prolonged fever were two independent factors associated with delayed resolution of pneumonitis, in this non-randomized, retrospective analysis. Conclusion Resolution of pneumonitis is delayed in some patients during SARS recovery and may be associated with delayed clearance of coronavirus, Complete resolution may occur by 90 days or later. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource SARS, alveolar macrophages, T lymphocyte, coronavirus, cytokines, bronchoalveolar lavage Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1465-9921-6-42 Source A related resource from which the described resource is derived Respiratory Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the respiratory system Language A language of the resource EN