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                <text>Dominio científico: Coronavirus</text>
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              <text>SARS Vaccine Development</text>
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              <text>Shibo Jiang, Yuxian He, Shuwen Liu</text>
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              <text>Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)–associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.</text>
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              <text>Keywords: SARS, SARS-CoV, spike protein, receptor-binding domain, Neutralizing epitone, vaccine</text>
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              <text>DOI: 10.3201/eid1107.050219</text>
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              <text>Emerging Infectious Diseases</text>
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              <text>Infectious and parasitic diseases, Medicine</text>
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          <name>Language</name>
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              <text>EN</text>
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