https://socictopen.socict.org/files/original/fef4a24a1f42d8d68e20a73c85f6e3d4.pdf 29f4d15760c687f44abc8c6cf52259cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats Creator An entity primarily responsible for making the resource Alegría Carrasco-Pancorbo, Lucía Olmo-García, Alejandra Vazquez, Estefania Sanchez-Rodriguez, Félix Vargas, Sebastián Montoro-Molina, Miguel Romero, Juan Antonio Espejo-Calvo, Pedro Vilchez, Sara Jaramillo, Rafael de la Torre, Montserrat Fito, María-Isabel Covas, Emilio Martínez de Victoria, Maria Dolores Mesa Description An account of the resource Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Endothelial function, Hypertension, Phenolic compounds, extra-virgin olive oil Identifier An unambiguous reference to the resource within a given context 10.3390/nu11081728 Source A related resource from which the described resource is derived Nutrients Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nutrition. Foods and food supply Relation A related resource <a href="https://www.mdpi.com/2072-6643/11/8/1728" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2072-6643/11/8/1728</a>