https://socictopen.socict.org/files/original/23b0754bf1b3ff6c184c2dd03fa0f895.pdf 321f6e94404fdeb132824bb0be561f3e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic? Creator An entity primarily responsible for making the resource Jin Ho Shin, Dae-Hee Kim, Hyeon Chang Kim, Ju Han Kim, Sungha Park, Eun Joo Cho, Hae-Young Lee, Kwang-Il Kim, Wook-Jin Chung, Sang Hyun Ihm, Il Suk Sohn, Wook Bum Pyun, Ki-Chul Sung, Sung Kee Ryu, on behalf of the Korean Society of Hypertension Description An account of the resource Abstract Antihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of death in the extremely old subject. During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. Severe Acute Respiratory Syndrome-Coronavirus-1 and 2 viral surface protein is known to attach angiotensin converting enzyme 2 (ACE2) on the cell membrane to facilitate viral entry into the cytoplasm. Despite the theoretical concerns of increased ACE2 expression by Renin-Angiotensin-Aldosterone system (RAS) blockade, there is no evidence that RAS inhibitors are harmful during COVID-19 infection and have in fact been shown to be beneficial in animal studies. Therefore, it is recommended to maintain RAS blockade during the current corona virus pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource infection, hypertension, SARS, SARS-CoV-2, COVID-19, 2019 novel coronavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40885-020-00144-0 Source A related resource from which the described resource is derived Clinical Hypertension Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Internal medicine, Medicine