Mesenchymal stem cells as a potential therapy for COVID-19

Mesenchymal stem cells as a potential therapy for COVID-19

Shan LIU, Ke Yang, Lin Zou, Zhou Fu, Danyi Peng, Huijun Qiu

Abstract The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. The main pathologic features of severe or critical COVID-19 were consistent with acute lung injure (ALI)/acute respiratory distress syndrome (ARDS), characterized by cellular fibromyxoid exudates, extensive pulmonary inflammation, pulmonary edema, and hyaline membrane formation. Mesenchymal stem cells (MSCs) can balance the inflammatory response and has been mentioned to be effective on ALI/ARDS from both infectious and noninfectious causes previously, presenting an important opportunity to be applied to COVID-19. In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19.

2020

ARDS, MSCs, Ali, COVID-19

DOI: 10.1186/s13287-020-01678-8

Stem Cell Research & Therapy

BMC

Medicine (General), Biochemistry