Potential SARS-CoV-2 Preimmune IgM Epitopes

Potential SARS-CoV-2 Preimmune IgM Epitopes

Peter K. Petrov, Velizar Shivarov, Anastas D Pashov

While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.

2020

IgM, epitope, mimotope, B-cell precursors, SARS-CoV-2

DOI: 10.3389/fimmu.2020.00932

Frontiers in Immunology

Frontiers Media S.A.

Immunologic diseases. Allergy