https://socictopen.socict.org/files/original/a12c9c23b645bc5c0d47c37a744f6866.pdf 8385b98aaac9137433e77d52fa27b8d5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2 Creator An entity primarily responsible for making the resource Stephen C. Harmer, Jules C. Hancox, Andrew F. James, Richard Bond, Aziza El Harchi, Alexander Carpenter, Owen J. Chambers, Oliver Hanington Description An account of the resource The COVID-19 pandemic is an unprecedented challenge and will require novel therapeutic strategies. Affected patients are likely to be at risk of arrhythmia due to underlying comorbidities, polypharmacy and the disease process. Importantly, a number of the medications likely to receive significant use can themselves, particularly in combination, be pro-arrhythmic. Drug-induced prolongation of the QT interval is primarily caused by inhibition of the hERG potassium channel either directly and/or by impaired channel trafficking. Concurrent use of multiple hERG-blocking drugs may have a synergistic rather than additive effect which, in addition to any pre-existing polypharmacy, critical illness or electrolyte imbalance, may significantly increase the risk of arrhythmia and Torsades de Pointes. Knowledge of these risks will allow informed decisions regarding appropriate therapeutics and monitoring to keep our patients safe. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource arrhythmia, Drug safety, hERG, QT, QTc, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fcvm.2020.00085 Source A related resource from which the described resource is derived Frontiers in Cardiovascular Medicine Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the circulatory (Cardiovascular) system