https://socictopen.socict.org/files/original/6756977e0896e03310a3e2f5a233eebc.pdf 9d88803d114e9fa2e9b581a9715bb32a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS−CoV−2 Infection: An <i>In−Silico</i> Investigation Creator An entity primarily responsible for making the resource Joyce Kelly R. da Silva, William N. Setzer, Kendall G. Byler, Pablo Luis Baia Figueiredo Description An account of the resource Essential oils have shown promise as antiviral agents against several pathogenic viruses. In this work we hypothesized that essential oil components may interact with key protein targets of the 2019 severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2). A molecular docking analysis was carried out using 171 essential oil components with SARS−CoV−2 main protease (SARS−CoV−2 Mpro), SARS−CoV−2 endoribonucleoase (SARS−CoV−2 Nsp15/NendoU), SARS−CoV−2 ADP−ribose−1″−phosphatase (SARS−CoV−2 ADRP), SARS−CoV−2 RNA−dependent RNA polymerase (SARS−CoV−2 RdRp), the binding domain of the SARS−CoV−2 spike protein (SARS−CoV−2 rS), and human angiotensin−converting enzyme (hACE2). The compound with the best normalized docking score to SARS−CoV−2 Mpro was the sesquiterpene hydrocarbon (E)−β−farnesene. The best docking ligands for SARS−CoV Nsp15/NendoU were (E,E)−α−farnesene, (E)−β−farnesene, and (E,E)−farnesol. (E,E)−Farnesol showed the most exothermic docking to SARS−CoV−2 ADRP. Unfortunately, the docking energies of (E,E)−α−farnesene, (E)−β−farnesene, and (E,E)−farnesol with SARS−CoV−2 targets were relatively weak compared to docking energies with other proteins and are, therefore, unlikely to interact with the virus targets. However, essential oil components may act synergistically, essential oils may potentiate other antiviral agents, or they may provide some relief of COVID−19 symptoms. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource essential oils, molecular docking, antiviral, coronavirus, COVID‐19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijms21103426 Source A related resource from which the described resource is derived International Journal of Molecular Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry