https://socictopen.socict.org/files/original/e288187522d6ba800c5f6c14a5c8691f.pdf 7b45cde64f6059476bde6bfd44e410c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19). Creator An entity primarily responsible for making the resource Kelvin Kai-Wang To, Kwok-yung Yuen, Fei-fei Yin, Jian-Piao Cai, Ivan Fan-Ngai Hung, Kenn Ka-Heng Chik, Zi-Wei Ye, Kai-ming Tang, Jianli Cao, Chris Chun-Yiu Chan, Ronghui Liang, Jasper Fuk-Woo Chan, Dong-Yan Jin, Shuofeng Yuan, Jessica Oi-Ling Tsang, Hin Chu Description An account of the resource The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. In this study, we investigated the anti-SARS-CoV-2 activities of 22 antiviral agents with known broad-spectrum antiviral activities against coronaviruses and/or other viruses. They were first evaluated in our primary screening in VeroE6 cells and then the most potent anti-SARS-CoV-2 antiviral agents were further evaluated using viral antigen expression, viral load reduction, and plaque reduction assays. In addition to remdesivir, lopinavir, and chloroquine, our primary screening additionally identified types I and II recombinant interferons, 25-hydroxycholesterol, and AM580 as the most potent anti-SARS-CoV-2 agents among the 22 antiviral agents. Betaferon (interferon-β1b) exhibited the most potent anti-SARS-CoV-2 activity in viral antigen expression, viral load reduction, and plaque reduction assays among the recombinant interferons. The lipogenesis modulators 25-hydroxycholesterol and AM580 exhibited EC50 at low micromolar levels and selectivity indices of >10.0. Combinational use of these host-based antiviral agents with virus-based antivirals to target different processes of the SARS-CoV-2 replication cycle should be evaluated in animal models and/or clinical trials. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource treatment, coronavirus, interferon, 25-hydroxycholesterol, COVID-19, AM580 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v12060628 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG