https://socictopen.socict.org/files/original/8dd36a940593fd88ff45a5915e23afd0.pdf 851fe7e4779462c41c102fb1bfb520bf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition Creator An entity primarily responsible for making the resource Hui Zhang, Min Yao, Dan Wang, Yuan Wang, Liang Zhang, Wei Ye, He Liu, Lin-Feng Cheng, Zhi-Kai Xu, Fang-Lin Zhang, XIN LV, Hong-wei MA, Yingfeng Lei, Chuantao Ye, Yue-Wu Yang, Yangchao Dong, Libin Qi Description An account of the resource Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy. Thus, a therapeutic agent for the enterovirus-related disease is urgently needed. Remdesivir (GS-5734) is a novel monophosphoramidate adenosine analog prodrug that exhibits potent antiviral activity against diverse RNA virus families, including positive-sense Coronaviridae and Flaviviridae and negative-sense Filoviridae, Paramyxoviridae, and Pneumoviridae. Currently, remdesivir is under phase 3 clinical development for disease COVID-19 treatment. Here, we found that remdesivir impeded both EV71 viral RNA (vRNA) and complementary (cRNA) synthesis, indicating that EV71 replication is inhibited by the triphosphate (TP) form of remdesivir. Moreover, remdesivir showed potent antiviral activity against diverse enteroviruses. These data extend the remdesivir antiviral activity to enteroviruses and indicate that remdesivir is a promising antiviral treatment for EV71 and other enterovirus infections. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource antivirals, Enterovirus, EV71, vRNA, crna, remdesivir (gs-5734) Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2020.01105 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology