Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets

Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets

Debdulal Banerjee, Hiran Kanti Santra

COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economicdisaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS andMERS it’s structural and sequence similarity has abled scientists for repurposing of popular drugs likehydroxychloroquine, cloroquine and also scavenging for lead molecules by in-silico and in-vivo or in-vitroapproach. The potent drug targets are ACE2; spike protein binding receptor to host cell surface, Mpro;proteo-lytic polyprotein processing enzymes needed for virion maturation and RdRp; RNA dependentRNA polymerase needed for RNA replication. The recent trend focuses on the fact that cocktail of anticorona virus treatment will be available soon by broad spectrum antiviral compounds. It takes timeto develop such drug targets till then social distancing and following of hygiene are the only way tothrive well. This article incorporates the present World scenario related to COVID infection, focuseson its origin and also future possibilities for a COVID free future.

2020

in vitro, in vivo, ACE2, in silico, Broad-spectrum, RdRp, COVID-19, MPro

DOI: 10.22207/JPAM.14.SPL1.17

Journal of Pure and Applied Microbiology

Journal of Pure and Applied Microbiology

Microbiology