Nitenpyram analogues with 1,4-dihydropyridine fixed cis-configuration:synthesis,insecticidal activities and molecular docking studies

Nitenpyram analogues with 1,4-dihydropyridine fixed cis-configuration:synthesis,insecticidal activities and molecular docking studies

XUE Sijia, PANG Chuncheng, CHEN Yanxia, LIU Tianyan

A novel series of Nitenpyram analogues(Ia-Ij) with 1,4-dihydropyridine fixed cis-configuration were designed and synthesized.Preliminary bioassays showed that most of them exhibited good insecticidal activities against Aphis medicagini and Brown rice planthopper at 500 mg/L and 100 mg/L.The analogue Ij afforded the best activity in vitro,that had 100% mortality at 4 mg/L against Brown rice planthopper and Aphis medicagin.In addition,the molecular docking simulations revealed that the structural uniqueness of these analogues may lead to a unique molecular recognition and binding mode,and the results explained the SARs observed in vitro, which shed light on the novel insecticidal mechanism of these novel nitenpyam analogues.

2013

cis-Nitenpyram analogue, 1, 4-Dihydropyridine, Synthesis, insecticidal acvitity, molecular docking

DOI:

Journal of Shanghai Normal University (Natural Sciences)

Academic Journals Center of Shanghai Normal University

Science (General)

EN, ZH