https://socictopen.socict.org/files/original/d7681236c969596ebb736f4276fd49ed.pdf 3f26a82ad721cb1a4d466ddffd647226 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19. Creator An entity primarily responsible for making the resource Bertram Pitt, Nadia R Sutton, Zhong Wang, Sascha N Goonewardena, Michael Holinstat Description An account of the resource There is a need for therapeutic approaches to prevent and mitigate the effects of Coronavirus Disease (2019) (COVID-19). The histone deacetylase (HDAC) inhibitor valproic acid, which has been available for the therapy of epilepsy for many years, is a drug that could be repurposed for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This article will review the reasons to consider valproic acid as a potential therapeutic to prevent severe COVID-19. Valproic acid could reduce angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, required for SARS-CoV-2 viral entry, and modulate the immune cellular and cytokine response to infection, thereby reducing end-organ damage. The combined anti-thrombotic, anti-platelet, and anti-inflammatory effects of valproic acid suggest it could be a promising therapeutic target for COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource severe acute respiratory syndrome, covid-19, acute respiratory distress syndrome, Valproic acid, Histone deacetylase inhibitor Identifier An unambiguous reference to the resource within a given context 10.1016/j.ejphar.2021.173988 Source A related resource from which the described resource is derived European journal of pharmacology