https://socictopen.socict.org/files/original/b07b92ce720e017544aed23ee4963c4d.pdf 2a021b886401457f223d812a007b3740 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comorbidities and clinical severity of COVID-19: systematic review and meta-analysis Creator An entity primarily responsible for making the resource Thais María Plasencia-Urizarri, Raúl Aguilera-Rodríguez, Luis Enrique Almaguer Mederos Description An account of the resource Introduction: The recent emergence of COVID-19 has become a serious global health problem. The identification of comorbidities associated with the clinical severity in COVID-19 patients is of paramount significance for the appropriate therapeutic approach of affected patients.Objective: To evaluate the risk of severe clinical presentation of COVID-19 in patients with comorbidities.Materials and methods: A systematic literature search and meta-analysis was conducted in specialized databases to obtain information from articles published until March 20, 2020. All relevant papers with information on the association between clinical severity and comorbidities were included. The odds ratio with 95 % confidence interval and fixed or random effect models were used. Results: Thirteen studies were included for a total of 99 817 patients. Global effects were obtained for hypertension (OR: 4.05; 95 % CI: 3.45-4.74), cardiovascular disease (OR: 4.39; 95 % CI: 3.29-5.87), diabetes mellitus (OR: 3.53; 95 % CI: 2.79-4.47), smoking (OR: 2.87; 95 % CI: 1.81-4.54), chronic lung disease (OR: 2.73; 95 % CI: 2.55-2.94), chronic kidney disease (OR: 5.60; 95 % CI: 4.13-7.60), chronic liver disease (OR: 1.98; 95 % CI: 1.08-3.64), and immunodeficiency (OR: 2.90; 95 % CI: 2.06-4.09) in severe patients compared with non-severe patients.Conclusions: Chronic kidney disease, cardiovascular disease, hypertension and diabetes are among the comorbidities with the highest risk of severe clinical presentation in COVID-19 patients, followed in importance by immunodeficiency, smoking, chronic lung disease and chronic liver disease. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, comorbilidades, meta-análisis, gravedad clínica Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Medicine (General)