Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids

Zhen Liang, Hang Xu, Ye Tian, Mengbi Guo, Xin Su, Chun Guo

A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.

2016

Antifungal activity, N-myristoyltransferase, benzofuran, 1, 2, 3-triazole, Click chemistry, molecule hybrid

DOI: 10.3390/molecules21060732

Molecules

MDPI AG

Organic chemistry

EN