Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
Título
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
Autor
Jamie L. Everman, Jose Rodriguez-Santana, Max A. Seibold, Kenneth M. Rice, Michael E. Wechsler, Michael C. Zody, Celeste Eng, Soren Germer, Deborah A. Nickerson, Esteban G. Burchard, Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Angel C. Y. Mak, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Gonçalo Abecasis, Hyun Min Kang, Rajesh Kumar, Sam Oh
Descripción
ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.
Fecha
2020
Identificador
10.1038/s41467-020-18781-2
Fuente
Epidemiology and Health
Editor
Korean Society of Epidemiology
Cobertura
Science
Archivos
Colección
Citación
Jamie L. Everman, Jose Rodriguez-Santana, Max A. Seibold, Kenneth M. Rice, Michael E. Wechsler, Michael C. Zody, Celeste Eng, Soren Germer, Deborah A. Nickerson, Esteban G. Burchard, Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Angel C. Y. Mak, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Gonçalo Abecasis, Hyun Min Kang, Rajesh Kumar, Sam Oh, “Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium,” SOCICT Open, consulta 18 de abril de 2026, https://socictopen.socict.org/items/show/5302.
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