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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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          <name>Title</name>
          <description>A name given to the resource</description>
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              <text>Antimalarial Activity of Ultra-Short Peptides</text>
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          <name>Creator</name>
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              <text>María Yolanda Rios, A. Berenice Aguilar-Guadarrama, Rocío Argotte-Ramos, Lemuel Pérez-Picaso, Benjamín Velasco-Bejarano</text>
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              <text>Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.</text>
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              <text>2009</text>
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              <text>tetrapeptides, antimalarial activity, Plasmodium berghei, ultra-short peptides</text>
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              <text>DOI: 10.3390/molecules14125103</text>
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              <text>Molecules</text>
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              <text>MDPI AG</text>
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          <name>Coverage</name>
          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Organic chemistry</text>
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          <name>Language</name>
          <description>A language of the resource</description>
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              <text>EN</text>
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