Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19

Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19

Adam Klocperk, Zuzana Parackova, Jitka Dissou, Hana Malcova, Petr Pavlicek, Tomas Vymazal, Pavla Dolezalova, Anna Sediva

We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.

2020

covid-19, SARS-CoV-2, PIMS-TS, innate immunity, hemophagocytic lymphohistiocytosis, macrophage activation syndrome

10.3389/fimmu.2020.01665

Epidemiology and Health

Korean Society of Epidemiology

Immunologic diseases. Allergy