https://socictopen.socict.org/files/original/ff19cb99b62c5df12ef2735db91bf4fd.pdf 46c9843704747cab8b45d4e7e0f8b92a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19. Creator An entity primarily responsible for making the resource Trevor D Scobey, Deli Huang, David Nemazee, Jason S McLellan, Lisa E Gralinski, Ralph S Baric, Longping V Tse, C Garrett Rappazzo, Chengzi I Kaku, Daniel Wrapp, Mrunal Sakharkar, Laura M Deveau, Thomas J Yockachonis, Andrew S Herbert, Michael B Battles, Cecilia M O'Brien, Michael E Brown, James C Geoghegan, Jonathan Belk, Linghang Peng, Linlin Yang, Dennis R Burton, John M Dye, James E Voss, Bronwyn M Gunn, Laura M Walker Description An account of the resource The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. Here, we employed a directed evolution approach to engineer three SARS-CoV-2 antibodies for enhanced neutralization breadth and potency. One of the affinity-matured variants, ADG-2, displays strong binding activity to a large panel of sarbecovirus receptor binding domains (RBDs) and neutralizes representative epidemic sarbecoviruses with remarkable potency. Structural and biochemical studies demonstrate that ADG-2 employs a unique angle of approach to recognize a highly conserved epitope overlapping the receptor binding site. In murine models of SARS-CoV and SARS-CoV-2 infection, passive transfer of ADG-2 provided complete protection against respiratory burden, viral replication in the lungs, and lung pathology. Altogether, ADG-2 represents a promising broad-spectrum therapeutic candidate for the treatment and prevention of SARS-CoV-2 and future emerging SARS-like CoVs. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1101/2020.11.17.385500 Source A related resource from which the described resource is derived bioRxiv : the preprint server for biology