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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease</text>
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              <text>Stephen L. Atkin, Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani, Salman Yousif Alali, Alaa Mahmood Al Zamrooni, Amal Hamza Hejab, Ronán M. Conroy, Pearl Wasif, Sameer Otoom, Manal Abduljalil</text>
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              <text>Abstract Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters and mortality at 28 days. The CP group were a higher risk group with higher ferritin levels (p </text>
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              <text>2021</text>
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              <text>10.1038/s41598-021-89444-5</text>
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              <text>Epidemiology and Health</text>
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              <text>Korean Society of Epidemiology</text>
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              <text>Science, Medicine</text>
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