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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Coronavirus</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Dominio científico: Coronavirus</text>
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          <name>Title</name>
          <description>A name given to the resource</description>
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              <text>O Papel da Imunidade Inata na COVID-19</text>
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          <name>Creator</name>
          <description>An entity primarily responsible for making the resource</description>
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              <text>Mariléia Chaves Andrade, Luiz Henrique  Silva de Sordi, Isabela Sales Oliveira Magalhães, Daniela  Abreu Casselhas</text>
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          <name>Description</name>
          <description>An account of the resource</description>
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              <text>O sistema imune apresenta papel importante na pandemia da COVID-19, pois está envolvido na patogênese e agravamento da doença. O objetivo desta revisão é abordar os aspectos da imunidade inata na COVID-19, especialmente o papel dos neutrófilos. O sistema imune inato corresponde à primeira defesa do organismo, porém é necessário um equilíbrio para obter efetividade contra o invasor sem lesar excessivamente o hospedeiro. O desequilíbrio imune está relacionado com quadros mais graves e à ativação aberrante de neutrófilos, sendo a linfopenia e a neutrofilia preditores de pior prognóstico em pacientes com COVID-19.  Especula-se que a neutrofilia seja uma importante fonte para formação excessiva de NET (Neutrophil Extracellular Traps), levando ao aumento da resposta inflamatória e evolução desfavorável da doença. As NET também estão associadas à tempestade de citocinas, outro mecanismo relacionado a gravidade da COVID-19. Portanto, estratégias que envolvam a imunomodulação podem ter um papel importante no controle da doença.</text>
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          <name>Date</name>
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              <text>2020</text>
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          <name>Subject</name>
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              <text>infecções por coronavírus, neutrófilos, imunidade inata, armadilhas extracelulares</text>
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          <name>Identifier</name>
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              <text>10.21876/rcshci.v10i3.997</text>
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          <name>Source</name>
          <description>A related resource from which the described resource is derived</description>
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              <text>Epidemiology and Health</text>
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          <name>Publisher</name>
          <description>An entity responsible for making the resource available</description>
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              <text>Korean Society of Epidemiology</text>
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          <name>Coverage</name>
          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Medicine (General), Nursing</text>
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