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                <text>Dominio científico: Coronavirus</text>
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              <text>CRISPR-Based COVID-19 Testing: Toward Next-Generation Point-of-Care Diagnostics</text>
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              <text>Uyanga Ganbaatar, Uyanga Ganbaatar, Changchun Liu</text>
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              <text>As the COVID-19 pandemic continues, people are becoming infected at an alarming rate, individuals are unknowingly spreading disease, and more lives are lost every day. There is an immediate need for a simple, rapid, early and sensitive point-of-care testing for COVID-19 disease. However, current testing approaches do not meet such need. Recently, clustered regularly interspaced short palindromic repeats (CRISPR)-based detection methods have received substantial attention for nucleic acid-based molecular testing due to their simplicity, high sensitivity and specificity. This review explores the various CRISPR-based COVID-19 detection methods and related diagnostic devices. As with any emerging technology, CRISPR/Cas-based nucleic acid testing methods have several challenges that must be overcome for practical applications in clinics and hospitals. More importantly, these detection methods are not limited to COVID-19 but can be applied to detect any type of pathogen, virus, and fungi that may threaten humans, agriculture, and food industries in resource-limited settings. CRISPR/Cas-based detection methods have the potential to become simpler, more reliable, more affordable, and faster in the near future, which is highly important for achieving point-of-care diagnostics.</text>
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              <text>coronavirus, covid-19, SARS-CoV-2, point-of-care testing, CRISPR-based nucleic acid detection</text>
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              <text>Epidemiology and Health</text>
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              <text>Korean Society of Epidemiology</text>
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          <name>Coverage</name>
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              <text>Microbiology</text>
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