https://socictopen.socict.org/files/original/385ac4dc8ae7d6066d29e4996bc34b2c.pdf a2ccdd05cf3e50d103ac15dc9fcb4571 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods Creator An entity primarily responsible for making the resource Carmen Gil, Ana Martínez, Vanesa Nozal, Tiziana Ginex, Urtzi Garaigorta, David Ramírez, Victoria Castro, Inés Maestro, Javier García-Cárceles, Nuria E. Campillo, Pablo Gastaminza Description An account of the resource The unprecedent situation generated by the COVID-19 global emergency has prompted us to actively work to fight against this pandemic by searching for repurposable agents among FDA approved drugs to shed light into immediate opportunities for the treatment of COVID-19 patients. In the attempt to proceed toward a proper rationalization of the search for new antivirals among approved drugs, we carried out a hierarchical in silico/in vitro protocol which successfully combines virtual and biological screening to speed up the identification of host-directed therapies against COVID-19 in an effective way. To this end a multi-target virtual screening approach focused on host-based targets related to viral entry, followed by the experimental evaluation of the antiviral activity of selected compounds, has been carried out. As a result, five different potentially repurposable drugs interfering with viral entry—cepharantine, clofazimine, metergoline, imatinib and efloxate—have been identified. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, drug repurposing, virtual screening, entry inhibitors, SARS-CoV-2 evaluation, host-based targets Identifier An unambiguous reference to the resource within a given context 10.3390/ph14040332 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Pharmacy and materia medica