https://socictopen.socict.org/files/original/f4461aab919bb1e00996e6f3d4336374.pdf 15c7bbc55b08d799d169e2163ece96fe Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities Creator An entity primarily responsible for making the resource Ute Hentschel, Chris M. Ireland, Tanja Schirmeister, Jason Reppart, Gerhard Bringmann, Tobias A. M. Gulder, Tim S. Bugni, Verena Buback, Sheila M. Pimentel-Elardo Description An account of the resource Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV Mpro, and PLpro. The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteases with Ki values in the low micromolar range. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource tetromycin, anti-trypanosomal, protease inhibition, Streptomyces axinellae, marine sponge Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/md9101682 Source A related resource from which the described resource is derived Marine Drugs Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN