https://socictopen.socict.org/files/original/8b7d797c34ffcb982fd5effeac4f55b5.pdf abc17579645b85c0b0f003c817d1e5a2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Conformational flexibility and structural variability of SARS-CoV2 S protein. Creator An entity primarily responsible for making the resource Ishika Pramanick, Nayanika Sengupta, Suman Mishra, Suman Pandey, Nidhi Girish, Alakta Das, Somnath Dutta Description An account of the resource Spike (S) glycoprotein of SARS-CoV2 exists chiefly in two conformations, open and closed. Most previous structural studies on S protein have been conducted at pH 8.0, but knowledge of the conformational propensities under both physiological and endosomal pH conditions is important to inform vaccine development. Our current study employed single-particle cryoelectron microscopy to visualize multiple states of open and closed conformations of S protein at physiological pH 7.4 and near-physiological pH 6.5 and pH 8.0. Propensities of open and closed conformations were found to differ with pH changes, whereby around 68% of S protein exists in open conformation at pH 7.4. Furthermore, we noticed a continuous movement in the N-terminal domain, receptor-binding domain (RBD), S2 domain, and stalk domain of S protein conformations at various pH values. Several key residues involving RBD-neutralizing epitopes are differentially exposed in each conformation. This study will assist in developing novel therapeutic measures against SARS-CoV2. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource cryo-EM, pH dependent, TEM, 3D reconstruction, S-head, negative staining, single particle, solvent accessibility, spike homotrimer, stalk domain Identifier An unambiguous reference to the resource within a given context 10.1016/j.str.2021.04.006 Source A related resource from which the described resource is derived Structure (London, England : 1993)