https://socictopen.socict.org/files/original/a37ea3c6b8a38182ec3b11591c289007.pdf 98947bbe2b93d0767e195e1d740a401b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early caloric deficit is associated with a higher risk of death in invasive ventilated COVID-19 patients. Creator An entity primarily responsible for making the resource Emanuele Cereda, Sara Masi, Silvia Crotti, Riccardo Caccialanza, Amedeo Guzzardella, Catherine Klersy, Mirko Belliato, Andrea Pellegrini, Fabio Sciutti, Silvia Mongodi, Monica Savioli, Alberto Zanella, Francesco Mojoli, Giacomo Grasselli Description An account of the resource The aim of this study was to evaluate the nutritional support management in mechanically ventilated coronavirus disease 2019 (COVID-19) patients and explore the association between early caloric deficit and mortality, taking possible confounders (i.e. obesity) into consideration. This was a prospective study carried out during the first pandemic wave in the intensive care units (ICUs) of two referral University Hospitals in Lombardy, Italy. Two hundred twenty-two consecutive mechanically ventilated COVID-19 patients were evaluated during the ICU stay. In addition to major demographic and clinical data, we recorded information on the route and amount of nutritional support provided on a daily basis. Among patients still in the ICUs and alive on day 4 (N = 198), 129 (65.2%) and 72 (36.4%) reached a satisfactory caloric and protein intake, respectively, mainly by enteral route. In multivariable analysis, a satisfactory caloric intake on day 4 was associated with lower mortality (HR = 0.46 [95%CI, 0.42-0.50], P < 0.001). Mild obesity (body mass index [BMI] ≥30 and < 35 kg/m2) was associated with higher mortality (HR = 1.99 [95%CI, 1.07-3.68], P = 0.029), while patients with moderate-severe obesity (BMI≥35 kg/m2) were less likely to be weaned from invasive mechanical ventilation (HR = 0.71 [95%CI, 0.62-0.82], P < 0.001). This study confirmed the negative prognostic and clinical role of obesity in mechanically ventilated COVID-19 patients and suggested that early caloric deficit may independently contribute to worsen survival in this patients' population. Therefore, any effort should be made to implement an adequate timely nutritional support in all COVID-19 patients during the ICU stay. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource mortality, Coronavirus disease 2019, mechanical ventilation, obesity, Nutritional support, Early caloric deficit Identifier An unambiguous reference to the resource within a given context 10.1016/j.clnu.2021.02.020 Source A related resource from which the described resource is derived Clinical nutrition (Edinburgh, Scotland)