The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis

The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis

Almigdad H. M. Ali, Sagad Omer Obeid Mohamed, Ibrahim H. E. Elkhidir, Mohamed Elata Hassan Elbathani, Abazr A. H. Ibrahim, Almutasim B. E. Elhassan, Mohammed Suliman Tawer Salman, Mazin A.M. Elhassan, Mahmoud Elnil, Abdelhamid Ibrahim Hassan Abuzied

Background: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms. Objectives: This review aims to investigate the association of lymphocyte count, CRP, LDH, and D-Dimer with the severity of COVID-19. Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases of MEDLINE/PubMed, WHO-Virtual Health Library (VHL), and ScienceDirect were used for the systematic search. Random effects model was used to estimate the pooled standardized mean differences (SMD) with the corresponding 95% confidence interval (CI), using OpenMeta Analyst software. Results: A total of 11 studies, with 2437 COVID-19 patients, which fulfilled the eligibility criteria were included in the meta-analysis. The analysis revealed that lymphocyte count was significantly lower in patients with the severe form of COVID-19 (SMD = - 1.025, P value

2020

covid-19, CRP, D-dimer, Meta-analysis, Lymphocyte count, LDH

10.18502/sjms.v15i5.7146

Epidemiology and Health

Korean Society of Epidemiology

Medicine