https://socictopen.socict.org/files/original/b5bb74c6d0ab0c2471fcde3828076096.pdf 5497ed2da1d2a5e3b9b978eede3c4db6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular stability of a vaccine strain of Canine coronavirus after serial passages in A72 cells Creator An entity primarily responsible for making the resource Iracema Nunes de Barros, Sheila Oliveira de Souza Silva, Sueli Akemi Tanikawi, Paulo Eduardo Brandão Description An account of the resource Canine coronavirus (CCoV) exists in types I and II and infects dogs leading mainly to enteritis, though type II has already been associated with generalized and highly lethal infection. A CCoV-type II inactivated vaccine produced in A72 canine cells is available worldwide and largely used, though the molecular stability after serial passages of vaccine seeds is unknown. This article reports the evolution of the CCoV-II vaccine strain 1-71 in A72 cells based on partial S gene sequencing, showing the predominance of neutral evolution and the occurrence of four sites under purifying selection. Thus, cell-adapted strains of CCoV-II may be genetically stable after serial passages in a same cell line due to a stable virus-host relationship. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource evolution, vaccine, Canine coronavirus, passages, A72 cells Identifier An unambiguous reference to the resource within a given context 10.11606/issn.1678-4456.bjvras.2017.111310 Source A related resource from which the described resource is derived Brazilian Journal of Veterinary Research and Animal Science Publisher An entity responsible for making the resource available Universidade de São Paulo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Animal culture