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                <text>Dominio científico: Coronavirus</text>
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              <text>Landscape of humoral immune responses against SARS-CoV-2 in patients with COVID-19 disease and the value of antibody testing.</text>
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              <text>Sundarasamy Mahalingam, John Peter, Vaniambadi S. Kalyanaraman, Alagarsamy Srinivasan, Ziyang Xu, Devivasha Bordoloi, Michelle Ho, Kar Muthumani</text>
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              <text>A new pandemic is ongoing in several parts of the world. The agent responsible is the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The symptoms associated with this virus are known as the coronavirus disease-2019 (COVID-19). In this review, we summarize the published data on virus specific antibodies in hospitalized patients with COVID-19 disease, patients recovered from the disease and the individuals who are asymptomatic with SARS-CoV-2 infections. The review highlights the following: i) an adjunct role of antibody tests in the diagnosis of COVID-19 in combination with RT-PCR; ii) status of antibodies from COVID-19 convalescent patients to select donors for plasma therapy; iii) the potential confounding effects of other coronaviruses, measles, mumps and rubella in antibody testing due to homology of certain viral genes; and iv) the role of antibody testing for conducting surveillance in populations, incidence estimation, contact tracing and epidemiologic studies.</text>
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              <text>2021</text>
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              <text>RT-PCR, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), antibody tests, Diagnosis of COVID-19</text>
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              <text>10.1016/j.heliyon.2021.e06836</text>
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