Biomolecular interactions with nanoparticles: applications for coronavirus disease 2019.

Biomolecular interactions with nanoparticles: applications for coronavirus disease 2019.

Mohammed A H Farouq, Mohammed M Al Qaraghuli, Karina Kubiak-Ossowska, Valerie A Ferro, Paul A Mulheran

Nanoparticles are small particles sized 1-100 nm, which have a large surface-to-volume ratio, allowing efficient adsorption of drugs, proteins, and other chemical compounds. Consequently, functionalized nanoparticles have potential diagnostic and therapeutic applications. A variety of nanoparticles have been studied, including those constructed from inorganic materials, biopolymers, and lipids. In this review, we focus on recent work targeting the severe acute respiratory syndrome coronavirus 2 virus that causes coronavirus disease (COVID-19). Understanding the interactions between coronavirus-specific proteins (such as the spike protein and its host cell receptor angiotensin-converting enzyme 2) with different nanoparticles paves the way to the development of new therapeutics and diagnostics that are urgently needed for the fight against COVID-19, and indeed for related future viral threats that may emerge.

2021

covid-19, diagnostics, SARS-CoV-2, nanoparticles, therapeutics, Proteins

10.1016/j.cocis.2021.101461

Current opinion in colloid & interface science