https://socictopen.socict.org/files/original/9c95195eb57e9895438d646d65ede0c6.pdf cda8644cdf7a6a7f38562f28c2f53267 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein. Creator An entity primarily responsible for making the resource Devan Diwanji, Melanie Ott, Kaitlin Schaefer, Zara Y Weinberg, Claire E Hilburger, Matthew Kim, Longxing Cao, Mir Khalid, Sarah Elmes, Evelyn Hernandez, Jocelyne Lopez, Amber M Smith, Fengbo Zhou, G Renuka Kumar, David Baker, Hana El-Samad Description An account of the resource The COVID-19 pandemic has demonstrated the need for exploring different diagnostic and therapeutic modalities to tackle future viral threats. In this vein, we propose the idea of sentinel cells, cellular biosensors capable of detecting viral antigens and responding to them with customizable responses. Using SARS-CoV-2 as a test case, we developed a live cell sensor (SARSNotch) using a de novo-designed protein binder against the SARS-CoV-2 Spike protein. SARSNotch is capable of driving custom genetically-encoded payloads in immortalized cell lines or in primary T lymphocytes in response to purified SARS-CoV-2 Spike or in the presence of Spike-expressing cells. Furthermore, SARSNotch is functional in a cellular system used in directed evolution platforms for development of better binders or therapeutics. In keeping with the rapid dissemination of scientific knowledge that has characterized the incredible scientific response to the ongoing pandemic, we extend an open invitation for others to make use of and improve SARSNotch sentinel cells in the hopes of unlocking the potential of the next generation of smart antiviral therapeutics. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1101/2021.04.20.440678 Source A related resource from which the described resource is derived bioRxiv : the preprint server for biology