Massive intraperitoneal hemorrhage in patients with COVID-19: a case series.
covid-19, coagulopathy, disseminated intravascular coagulation, thrombotic microangiopathy
Coronavirus disease (COVID-19) initiates several life-threatening complications including coagulopathies with a unique characteristic that made this problem challenging. Here we presented 4 cases of RT-PCR positive patients that have experienced deadly intraperitoneal hemorrhage with fourth WHO Bleeding Grade after overcoming their respiratory phase. COVID-19 could induce several coagulopathies with different features that besides iatrogenic interventions increases its mortality and morbidity due to lack of clinical evidence based on well-designed randomized clinical trials on anticoagulation therapies (AT) and administration of varieties of newly approved and non-approved medicines. This report showed the urgent need for investigation on the pathophysiology of COVID-19-associated coagulopathy esp. in hemorrhagic events which are needed to make the best therapeutic decision.
Vahid Reisi-Vanani, Zahra Lorigooini, Mohamad Ali Dayani, Mehrandokht Mardani, Fereidoun Rahmani