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            <name>Title</name>
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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Comparative diagnostic performance of rapid antigen detection tests for COVID-19 in a hospital setting.</text>
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              <text>Bianca Bruzzone, Vanessa De Pace, Patrizia Caligiuri, Valentina Ricucci, Giulia Guarona, Beatrice M. Pennati, Simona Boccotti, Andrea Orsi, Giorgio Da Rin, Giancarlo Icardi, Alexander Domnich</text>
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              <text>The availability of accurate and rapid diagnostic tools for COVID-19 is essential for tackling the ongoing pandemic. Our study aimed to quantify the performance of available antigen-detecting rapid diagnostic tests (Ag-RDTs) in a real-world hospital setting. In this retrospective analysis, the diagnostic performance of 7 Ag-RDTs was compared with real-time reverse transcription quantitative polymerase chain reaction assay in terms of sensitivity, specificity and expected predictive values. A total of 321 matched Ag-RDTreal-time reverse transcription quantitative polymerase chain reaction samples were analyzed retrospectively. The overall sensitivity and specificity of the Ag-RDTs was 78.7% and 100%, respectively. However, a wide range of sensitivity estimates by brand (66.0%-93.8%) and cycle threshold (Ct) cut-off values (Ct &lt;25: 96.2%; Ct 30-35: 31.1%) was observed. The optimal Ct cut-off value that maximized sensitivity was 29. The routine use of Ag-RDTs may be convenient in moderate-to-high intensity settings when high volumes of specimens are tested every day. However, the diagnostic performance of the commercially available tests may differ substantially.</text>
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              <text>2021</text>
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              <text>covid-19, Italy, SARS-CoV-2, Rapid Antigen Detection Test</text>
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              <text>10.1016/j.ijid.2021.04.072</text>
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              <text>International Journal of Infectious Diseases</text>
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              <text>Elsevier</text>
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