https://socictopen.socict.org/files/original/458bbd0c29523e361587cd2e975fec0a.pdf e52db17e81b3e9b24a7cecab5bf1053f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Targeting protein-protein interaction interfaces in COVID-19 drug discovery. Creator An entity primarily responsible for making the resource Chung-ke Chang, Shan-Meng Lin, Shih-Chao Lin, Sin-Cih Sun, Hung-Yi Wu, Roshan Satange, Kylene Kehn-Hall, Ming-Hon Hou Description An account of the resource To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the SARS-CoV-2. Targeting relevant protein-protein interaction interfaces (PPIIs) is a viable paradigm for the design of antiviral drugs and enriches the targetable chemical space by providing alternative targets for drug discovery. In this review, we will provide a comprehensive overview of the theory, methods and applications of PPII-targeted drug development towards COVID-19 based on recent literature. We will also highlight novel developments, such as the successful use of non-native protein-protein interactions as targets for antiviral drug screening. We hope that this review may serve as an entry point for those interested in applying PPIIs towards COVID-19 drug discovery and speed up drug development against the pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, drug discovery, antiviral strategy, PPIIs Identifier An unambiguous reference to the resource within a given context 10.1016/j.csbj.2021.04.003 Source A related resource from which the described resource is derived Computational and structural biotechnology journal