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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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          <name>Title</name>
          <description>A name given to the resource</description>
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              <text>Familial hypercholesterolemia and statins in the COVID-19 era: Mitigating the risk of ischemic stroke.</text>
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              <text>Petri  T. Kovanen, Alpo Vuorio, Markku Kaste</text>
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              <text>There is a continuing need for research about the underlying mechanisms behind ischemic strokes in COVID-19 patients. Pre-existing endothelial dysfunction, especially if it is accompanied by a viral infection of the endothelial cells may present an important mechanism behind the immunothrombotic/thromboembolic complications of the COVID-19 illness. Here we emphasize that pharmacotherapy with statins could partly counteract such pathophysiological scenarios. Accordingly, using familial hypercholesterolemia (FH) as a pertinent example of a lifelong endothelial dysfunction, we aim to make the clinicians and consulting neurologists aware of statins as a possible adjuvant therapy in the context of an increased risk of ischemic stroke in patients with COVID-19. Based on recent clinical evidence, there is a need to encourage clinicians and consulting neurologists to continue or initiate effective statin treatment to prevent an ischemic stroke, particularly when they encounter a hypercholesterolemic COVID-19 patient with FH.</text>
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              <text>2021</text>
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              <text>covid-19, Stroke, Endothelial dysfunction, Statins, Familial hypercholesterolemia, LDL cholesterol</text>
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          <name>Identifier</name>
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              <text>10.1016/j.ensci.2021.100344</text>
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          <name>Source</name>
          <description>A related resource from which the described resource is derived</description>
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              <text>eNeurologicalSci</text>
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