Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses

Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses

Cristiane Angélica Ottoni, Marta Filipa Simões, André Antunes

Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further concern is the on-going emergence of antimicrobial resistance, which seriously limits treatment. The COVID-19 pandemic has worsened current circumstances and future infections will be more incident. It is urgent to plan, draw solutions, and act to mitigate these issues, namely by exploring new approaches. The aims of this review are to showcase the extensive research and application of silver nanoparticles (AgNPs) and other metal nanoparticles (MNPs) as antimicrobial agents. We highlight the advantages of mycogenic synthesis, and report on their underexplored potential as agents in the fight against all mycobacterioses (non-tuberculous mycobacterial infections as well as TB). We propose further exploration of this field.

2020

Filamentous Fungi, tuberculosis (TB), <i>Mycobacterium tuberculosis</i> (Mtb), Silver Nanoparticles (AgNp), metal nanoparticles (MNP), mycogenic synthesis

10.3390/antibiotics9090569

Epidemiology and Health

Korean Society of Epidemiology

Therapeutics. Pharmacology