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Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.
A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the partial duplication of the…
Position: 9948 (26 views)
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as…
Position: 1471 (57 views)
Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of…
Position: 9948 (26 views)
Identification of risks and vulnerabilities in senior citizens to COVID-19, a primary health care study
Background: senior citizens are those more vulnerable and with greater risk to progress to serious forms of COVID-19.Objective: to identify risks and vulnerabilities to COVID-19 in senior citizens older than 65 years of age belonging to the “Manuel…
Position: 14535 (21 views)
Identification of risk factors for mortality associated with COVID-19
Objectives Coronavirus Disease 2019 (COVID-19) has become a pandemic outbreak. Risk stratification at hospital admission is of vital importance for medical decision making and resource allocation. There is no sophisticated tool for this purpose. This…
Position: 6277 (32 views)
Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which…
Position: 13550 (22 views)
Identification of potential antiviral compounds against SARS-CoV-2 structural and non structural protein targets: A pharmacoinformatics study of the CAS COVID-19 dataset.
SARS-CoV-2 is a newly discovered virus which causes COVID-19 (coronavirus disease of 2019), initially documented as a human pathogen in 2019 in the city of Wuhan China, has now quickly spread across the globe with an urgency to develop effective…
Position: 12578 (23 views)
Identification of phosphate solubilizing bacteria in a Andisol of Colombian coffee region
Phosphorus is an essential nutrient for coffee growing, however, in Colombia most of the soils have low concentrations of this element. A strategy to supply the demand is the use of phosphate solubilizing microorganisms (PSM), in that order, 26…
Position: 6744 (31 views)
Identification of pathogens and virulence profile of Rhodococcus equi and Escherichia coli strains obtained from sand of parks
The identification of pathogens of viral (Rotavirus, Coronavirus), parasitic (Toxocara spp.) and bacterial (Escherichia coli, Salmonella spp., Rhodococcus equi) origin shed in feces, and the virulence profile of R. equi and E. coli isolates were…
Position: 15504 (20 views)
Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis
Background: Neuroinvasion of severe acute respiratory syndrome coronavirus (SARS-CoV) is well documented and, given the similarities between this virus and SARS-CoV-2, it seems that the neurological impairment that is associated with coronavirus…
Position: 13550 (22 views)