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Identification and Diagnosis of Newly Emerging Pathogens
Emerging infectious diseases (EIDs) are newly identified or known infectious diseases that have either expanded in geographic range or increased in infection prevalence over the previous two decades. During the last three decades, more than 30 EIDs…
Position: 1626 (56 views)
Identification and mapping of linear antibody epitopes in human serum albumin using high-density Peptide arrays.
We have recently developed a high-density photolithographic, peptide array technology with a theoretical upper limit of 2 million different peptides per array of 2 cm(2). Here, we have used this to perform complete and exhaustive analyses of linear B…
Position: 8022 (29 views)
Identification and survey of a novel avian coronavirus in ducks.
The rapid discovery of novel viruses using next generation sequencing (NGS) technologies including DNA-Seq and RNA-Seq, has greatly expanded our understanding of viral diversity in recent years. The timely identification of novel viruses using NGS…
Position: 1736 (55 views)
Identification of a conserved linear B-cell epitope in the M protein of porcine epidemic diarrhea virus
Abstract Background The major structural protein of coronaviruses, the membrane (M) protein, can elicit the formation of protective antibodies, but little information is available about the M protein of porcine epidemic diarrhea virus (PEDV).…
Position: 5617 (34 views)
Identification of a Membrane Binding Peptide in the Envelope Protein of MHV Coronavirus
Coronaviruses (CoVs) are enveloped, positive sense, single strand RNA viruses that cause respiratory, intestinal and neurological diseases in mammals and birds. Following replication, CoVs assemble on intracellular membranes including the endoplasmic…
Position: 13731 (22 views)
Identification of a mutation in the spike protein cleavage site in Brazilian strains of wild-type bovine coronavirus Identificação de uma mutação no sítio de clivagem da proteína da espícula em amostras brasileiras de coronavírus bovino
The spike (S) protein of coronaviruses, a type I membrane glycoprotein, is primarily responsible for entry into susceptible cells by binding with specific receptors on cells and mediating subsequent virus-cell fusion. The bovine coronavirus (BCoV) S…
Position: 18183 (17 views)
Identification of a Novel Betacoronavirus (<i>Merbecovirus</i>) in Amur Hedgehogs from China
While dromedaries are the immediate animal source of Middle East Respiratory Syndrome (MERS) epidemic, viruses related to MERS coronavirus (MERS-CoV) have also been found in bats as well as hedgehogs. To elucidate the evolution of MERS-CoV-related…
Position: 6427 (32 views)
Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV
Abstract Background The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent of severe acute respiratory syndrome (SARS). The S protein is a potent target for SARS-specific cell-mediated immune responses.…
Position: 14711 (21 views)
Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV
Abstract Background The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent of severe acute respiratory syndrome (SARS). The S protein is a potent target for SARS-specific cell-mediated immune responses.…
Position: 19403 (15 views)
Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we…
Position: 9356 (27 views)