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In Silico Discovery of Candidate Drugs against Covid-19
Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the cell to produce the final infection. In the present study we…
Position: 16568 (19 views)
In silico identification and validation of triarylchromones as potential inhibitor against main protease of severe acute respiratory syndrome coronavirus 2.
The ongoing pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused COVID-19 has emerged as a severe threat to the life of human kind. The identification and designing of appropriate and reliable drug molecule for the…
Position: 18193 (17 views)
In silico identification of vaccine targets for 2019-nCoV [version 1; peer review: 2 approved]
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people…
Position: 10999 (25 views)
In silico identification of vaccine targets for 2019-nCoV [version 1; peer review: 2 approved]
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people…
Position: 18193 (17 views)
In silico identification of vaccine targets for 2019-nCoV [version 2; peer review: 3 approved]
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people…
Position: 15665 (20 views)
In silico Molecular Docking Analysis Targeting SARSCoV-2 Spike Protein and Selected Herbal Constituents
In modern drug discovery, molecular docking analysis is routinely used to understand and predictthe interaction between a drug molecule and a target protein from a microbe. Drugs identified inthis way may inhibit the entry and replication of…
Position: 10169 (26 views)
In silico prediction of structure and function for a large family of transmembrane proteins that includes human Tmem41b [version 2; peer review: 1 approved, 2 approved with reservations]
Background: Recent strides in computational structural biology have opened up an opportunity to understand previously uncharacterised proteins. The under-representation of transmembrane proteins in the Protein Data Bank highlights the need to apply…
Position: 8738 (28 views)
In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes.
After the early advent of the Coronavirus Disease 2019 (COVID-19) pandemic, myriads of FDA-approved drugs have been massively repurposed for COVID-19 treatment based on molecular docking against selected protein targets that play fundamental roles in…
Position: 15665 (20 views)
In silico study of dynamic level interaction between CLF36 peptide and coronavirus surface protein in Bovine coronaviruses
Considering the fact that coronavirus is one of the major causes of calf diarrhea syndrome, this study aimed to investigate the interaction between the peptide cLF36 and the coronavirus protein by utilizing computational methods. Coronavirus amino…
Position: 17368 (18 views)
In silico Study of Pharmacological Treatments against SARS-CoV2 Main Protease
The COVID-19 caused by a new type of coronavirus has emerged from China and led to thousands ofdeath globally. Despite the efforts engaged in studying this newly emerged virus and searching for itstreatment, the understanding of the COVID-19 drug and…
Position: 9384 (27 views)