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The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases
When an antiviral immune response is generated, a balance must be reached between two opposing pathways: the production of proinflammatory and cytotoxic effectors that drive a robust antiviral immune response to control the infection and regulators…
Position: 7438 (30 views)
A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves
In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential…
Position: 4204 (39 views)
Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing.
Staphylococcus aureus strains of the 8325 lineage, especially 8325-4 and derivatives lacking prophage, have been used extensively for decades of research. We report herein the results of our deep sequence analysis of strain 8325-4. Assignment of…
Position: 5637 (34 views)
Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic.
Position: 11892 (24 views)
2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity…
Position: 6923 (31 views)
Clinical Characteristics of Patients Hospitalized with Coronavirus Disease, Thailand.
Among 11 patients in Thailand infected with severe acute respiratory syndrome coronavirus 2, we detected viral RNA in upper respiratory specimens a median of 14 days after illness onset and 9 days after fever resolution. We identified viral…
Position: 17355 (18 views)
Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors
Abstract Background RNA interference (RNAi) can potently reduce target gene expression in mammalian cells and is in wide use for loss-of-function studies. Several recent reports have demonstrated that short double-stranded RNAs (dsRNAs), used to…
Position: 9375 (27 views)
Efectos del cambio climático sobre la producción de papa en el municipio de Villapinzón (Cundinamarca-Colombia) a partir del Enfoque Ricardiano
La agricultura es uno de los sectores más vulnerables al cambio climático debido a su directa dependencia de las condiciones climáticas. Para medir los efectos del cambio climático sobre la agricultura se han desarrollado diferentes metodologías,…
Position: 5637 (34 views)
Evaluación de impactos ambientales en la cadena de producción de huevos agroecológicos con un enfoque de ciclo de vida
[Introducción]: Análisis de impactos ambientales en la producción de huevos, muestran diferencias significativas entre sistemas convencionales y orgánicos, relacionados con la alimentación, la eficiencia energética, la distribución y la gestión de…
Position: 10994 (25 views)
Stress and Coping in a Self-Isolated Family during COVID-19 Pandemic
Objective. To find out the level of stressfulness of inside family isolation in Russia; coping with the negative effects of a pandemic, fear and isolation.Background. The situation of a health threat causes unexpected stress enhancing the fear of…
Position: 18189 (17 views)