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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity. We recently reported…
Position: 9894 (26 views)
Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus <it>in vivo</it>
Abstract Background Infectious bronchitis virus (IBV) is first to be discovered coronavirus which is probably endemic in all regions with intensive impact on poultry production. In this study, we used two-dimensional gel electrophoresis (2-DE) and…
Position: 9135 (27 views)
Experimental Study of Hydrogen Addition Effects on a Swirl-Stabilized Methane-Air Flame
The effects of H2 addition on a premixed methane-air flame was studied experimentally with a swirl-stabilized gas turbine model combustor. Experiments with 0%, 25%, and 50% H2 molar fraction in the fuel mixture were conducted under atmospheric…
Position: 4842 (36 views)
CONFRONTO TRA IMMUNOFLUORESCENZA, NEUTRALIZZAZIONE E INDICE DI AVIDITA’ NELLA RILEVAZIONE DELLA RISPOSTA ANTICORPALE ANTI-SARS-CoV
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Position: 3490 (42 views)
Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems
For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their…
Position: 5477 (34 views)
Horizontal distribution of Cladocera in a subtropical lake marginal to a river
Various abiotic and biotic factors may determine the spatial distribution patterns of Cladocera in a lake. The aim of this study was to examine the horizontal distribution of Cladocera in a lake connected to a river during low and high water phases…
Position: 5838 (33 views)
Including the public in pandemic planning: a deliberative approach
Abstract Background Against a background of pandemic threat posed by SARS and avian H5N1 influenza, this study used deliberative forums to elucidate informed community perspectives on aspects of pandemic planning. Methods Two deliberative forums were…
Position: 7217 (30 views)
One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
Abstract Following the successful cloning of receptor for SARS coronavirus a few years ago, Dr. Wenhui Li and colleagues raised attention again by publishing a possible receptor for hepatitis B virus in eLife. We will briefly review the significance…
Position: 9135 (27 views)
Thirty Years of Research on Crown-of-Thorns Starfish (1986–2016): Scientific Advances and Emerging Opportunities
Research on the coral-eating crown-of-thorns starfish (CoTS) has waxed and waned over the last few decades, mostly in response to population outbreaks at specific locations. This review considers advances in our understanding of the biology and…
Position: 10692 (25 views)
SAR Imaging of Archaeological Sites on Intertidal Flats in the German Wadden Sea
We show that high-resolution space-borne synthetic aperture radar (SAR) imagery with pixel sizes smaller than 1 m2 can be used to complement archaeological surveys on intertidal flats. After major storm surges in the 14th and 17th centuries (“Grote…
Position: 3490 (42 views)